The loose bond formed between the two cell surfaces allows for the binding of T-cell receptors to the presented antigen. With the new system, these flows can be accelerated more than 30 times. Cell Reports,DOI: If one of these cells meets a foreign body, it will integrate parts from it — called antigens — onto its own cell surface and present these to other immune cells: The immune system protects the human body against pathogens thus keeping it healthy.
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In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly. Today, the researchers have published their results in the scientific journal Cell Reports.
If an immune cell recognises foreign matter, it can present it to another immune cell. This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them.
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Cell Reports,DOI: The large adhesion molecules accumulate around them in an outer ring.
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If all the components of the synapse are correctly positioned, activation of the immune cell will result.
With the previous technology — the simulation software ran on classic servers — the massive increase in computing power required for this would not have been possible, however, which is also due to the complexity of the German energy system, which has increased enormously in the course of the energy revolution.
With the new system, these flows can be accelerated more than 30 times.
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At the end of this process the T-cell is either activated or remains inactive. If an immune cell recognises foreign matter, it can present it to another immune cell. The grid operator uses extensive simulation tools to plan the construction and dimensioning of new power lines. Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information.